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download meTobacco use in a cohort of patients with coronary artery disease: prevalence, cause of death, and management strategies.
Tobacco use in patients with coronary artery disease (CAD) is common and associated with adverse outcomes. We examined mortality and hospital readmission in patients with CAD, with and without a diagnosis of tobacco use, and investigated management strategies used in the acute setting. Retrospective cohort study of patients with CAD admitted to a tertiary care hospital between 2000 and 2006. Patients with and without a diagnosis of tobacco use were compared using various outcomes, including mortality and postdischarge hospital readmission. Patients with tobacco use were older, more likely to have diabetes and hypertension, and less likely to have heart failure (HF). Patients with tobacco use were more likely to be admitted to the intensive care unit (ICU) and undergo percutaneous coronary intervention than patients without tobacco use. However, mortality rates were similar in patients with and without a diagnosis of tobacco use for all outcomes. The causes of death in patients with a diagnosis of tobacco use were predominantly non-cardiac. The in-hospital acute coronary syndrome management strategies were similar between patients with and without a diagnosis of tobacco use. Approximately 17% of patients with CAD with heart failure were smokers. There was no difference in in-hospital outcomes in patients with CAD regardless of the presence or absence of tobacco use, although study limitations cannot confirm whether tobacco use is a major factor in the development of HF. The causes of death in patients with CAD and a diagnosis of tobacco use were predominantly non-cardiac.The levels of p53 expression are a prognostic factor in patients with non-small-cell lung cancer.
The p53 gene is one of the most frequently inactivated tumor suppressor genes. We studied the p53 protein in 53 patients with non-small-cell lung cancer (NSCLC) by immunohistochemistry. Staining for the p53 protein was observed in 23 cases (43%) and more often in squamous-cell than in nonsquamous-cell NSCLC. The p53 positivity in tumours correlated with the stage of NSCLC, but not with the patients’ age, sex, histology, or tumor size. It was also associated with a poor survival of patients with squamous-cell carcinoma. However, univariate analysis showed no significant difference in survival between patients with p53-positive squamous-cell carcinoma and p53-

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